Female sterility due to an ovarian endocrine factor

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The ovarian endocrine factor is one of the causes why a woman can suffer sterility problems that prevent her from having a child.

It refers to any alteration in the hypothalamic-pituitary axis causing an imbalance in the production and release of hormones that intervene in the different stages of the ovarian cycle, compromising ovarian function and conditioning a disorder of the fertility of women.

Below you have an index with all the points that we will discuss in this article.

Index

This alteration can lead to the appearance of anovulatory cycles, associated with a wide range of menstrual changes. In this sense, differences between sporadic anovulatory cycles and chronic anovulatory processes are important.

Anovulation

Ovulation is the process by which a mature ovum leaves the ovarian follicle in the direction of the fallopian tubes waiting to be fertilized by the sperm to give rise to the embryo.

Ovulation problems

Anovulation consists in the absence of ovulation in an ovarian cycle. It can appear in all types of women and it is only worrisome if it becomes chronic:

  • Circumstantial Anovulation: almost all women have had an anovulation stage at some point in their lives due to stress, nerve, food deficiency, etc. In principle it is not something worrisome or serious. as long as it is sporadic.
  • Chronic Anovulation: it is due to long periods without ovulation that can be a cause of sterility since without ovulation, the ovum can never join the sperm to form a new being.

Causes of chronic anovulation

The prolonged or chronic absence of ovulations in ovarian cycles can be caused by several factors that the WHO (World Health Organization) classifies into different groups:

  • Group I or dysfunction of the hypothalamus and pituitary gland.
  • Group II or alteration of hypothalamic-pituitary secretion: includes polycystic ovarian syndrome.
  • Group III or primary or secondary ovarian failure.
  • Group V: women with hyperprolactinemia and evident lesion in the hypothalamic-pituitary axis.
  • Group VI: women with hyperprolactinemia and without evident lesion in the hypothalamic-pituitary axis.
  • Group VII or amenorrhea.
blood cell types

Ovulation and the menstrual cycle are regulated by the hormonal secretions of the hypothalamic-pituitary-ovarian axis. If there is any failure or alteration in this axis, the hormonal release is modified and this can cause the lack of ovulation or the alteration of the menstrual cycle, which can cause sterility.

Authors and collaborators

Andrea Rodrigo EmbriólogaLaunched in Biotechnology by the Polytechnic University of Valencia (UPV) with a Master's Degree in Biotechnology of Assisted Human Reproduction, taught by the University of Valencia in collaboration with the Valencian Infertility Institute (IVI). Postgraduate of Expert in Medical Genetics. More about Andrea RodrigoFollow us in our networks

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