Enzymes that maintain the health of the ovules

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Women are born with all the eggs they will use throughout their lives and they will be able to reproduce as long as they are healthy and in good condition. It is known that there are a number of specific genes responsible for keeping them in good shape but it is unknown how these genes are regulated.

According to a study published in the journal Science, it seems that there is an enzymatic group that plays a key role in this process.

Below you have an index with all the points that we will discuss in this article.

Index

The CLR4 complex improves female fertility

At work, the team of Chao Yu of the University of Hangzhou (China), has studied the role of a group of enzymes called CLR4 ligase complex, known to regulate various cellular signaling pathways.

The researchers tried to determine by various tests with mice if this complex also intervenes in the maintenance of the oocytes.

Their results show that two components of the CLR4 complex are essential to maintain the health of the ovules since if either of them is eliminated the infertility of the mice is provoked at very young ages.

On the other hand, the researchers designed mouse embryos without these two components, which causes the animals to lose the oocyte-producing follicles with those that were born at 12 weeks of age.

These findings suggest that the CLR4 complex is essential for the protection of oocytes and, therefore, also for the protection of the reproductive potential of women.

The study will help to better understand human reproduction because the mouse models used have infertility conditions more similar to humans and are therefore better than the animal models that were previously used in fertility studies.

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Bibliography

Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY. CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science 2013; 342 (6165): 1518-21.






freezing of pronucleate embryos in Tarragona(Spain)

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