Ovarian hyperstimulation syndrome: what is it and how is it cured?

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The ovarian hyperstimulation syndrome (OHSS) is an abnormally high response of the ovary to the medication that is administered in assisted reproduction treatments, especially in in vitro fertilization (IVF). It will be aggravated if pregnancy is achieved in that cycle.

Below you have an index with all the points that we will discuss in this article.

Index

Ovarian hyperstimulation syndrome: What is it and how is it cured?

What is it and when does the SHO appear?

This alteration is triggered in the luteal phase of the controlled ovarian stimulation cycles, after the administration of hCG (human chorionic gonadotropin). Only in the presence of this hormone does the excessive response that causes this syndrome occur.

It appears more frequently when in vitro fertilization (IVF) treatments are performed, compared to artificial insemination (AI), because the hormone doses administered in an IVF are higher than for an AI.

In an IVF treatment, the patient is given hormonal medication (gonadotropins) to stimulate the development of more follicles. Thus, we get more than one ovule to mature, which is what happens monthly in a natural cycle, under physiological conditions.

Causes of SHO

When this medication stimulates the ovary more sharply than expected, it may happen that the size of the ovaries will grow excessively and, after ovulation (release of the ovules), the escape of part of the fluid from the ovary to the area of the belly and chest.

The acute extravasation of fluids out of the bloodstream due to increased permeability of blood vessels can compromise the function of the hepatic, hematological, renal and respiratory systems, so that OHSS can become life-threatening in severe cases.

It is a syndrome of very limited duration, since it disappears with menstruation. But it must be controlled and followed up by transvaginal ultrasound, in case it leads to other more serious complications.

Currently, there are few cases of severe OHSS, since the type of ovarian stimulation protocols used and the analytical and ultrasonographic follow-up of follicular development allow to control the state and response of the ovary to medication and thus avoid the appearance of OHSS .





How can it be avoided?

As we have commented, the SHO appears in the presence of the hCG. Therefore, one way to prevent it is by avoiding the administration of this hormone.

One of the most common measures that can be followed in case of suspecting OHSS is to avoid triggering ovulation with hCG and using another type of medication, such as GnRH analogues.

Next we will explain in more detail some of the most used strategies to avoid the appearance of the SHO.

If you want to know more about how to prevent the occurrence of this problem, here are some keys to avoid the SHO.

Interview with Dr. Valeria Sotelo (IMFER)

In the following video, gynecologist Valeria Sotelo tells us what is the ovarian hyperstimulation syndrome, its symptoms and treatment to alleviate it.

Questions from users


freezing of ovarian tissue in Madrid(Spain)

Comments

  1. UnknownOctober 21, 2018 at 11:42 PM

    Well this blog was good. Would like to share some of my insights about OHSS.

    Worried about developing Ovarian Hyper Stimulation Syndrome (OHSS) during your IVF treatment? Visit, IVF Spring, Mumbai, a leading fertility clinic in India, and worry no more. We understand how OHSS is caused, and the risks it poses when the condition progresses. Our specialists work together to determine which patients have chances of developing Ovarian Hyper Stimulation Syndrome, and customize our fertility treatments to ensure that the risk factors are averted. For women with low body weight, Polycystic Ovary Syndrome (PCOS), high follicle count, and others who are at risk for OHSS, we use Mild Stimulation IVF or Natural Cycle IVF, which administer lesser to no medications, so that the body does not react badly to the treatment and develop OHSS. Our success rates are among the highest in the country, with no history of Ovarian Hyper Stimulation Syndrome in any of our treatments. We believe in giving our patients the highest standard of service, and personalized case, ensuring that two way communication takes place throughout the process, and no patient goes into the treatment feeling doubtful. At IVF Spring, Mumbai, we aspire for all our patients to experience the joy of parenthood.

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