Immunological infertility: types, causes and treatments

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Immune system disorders and autoimmune diseases can cause infertility in both men and women.

These alterations are difficult to diagnose, but approximately 20% of cases of infertility of unknown origin are due to some type of immune disorder.

Infertility of immunological origin has different ways of manifesting itself: it can destroy the gametes themselves, prevent the implantation of the embryo or even cause repeated spontaneous abortions.

Below you have an index with all the points that we will discuss in this article.

Index

Immune infertility: types, causes and treatments

What is the immune system?

The body's immune system is made up of a multitude of cells, molecules and mechanisms that protect the body from foreign agents, such as viruses, bacteria and other infectious agents that cause disease.

Some of the most important immune cells are lymphocytes or white blood cells, capable of recognizing their own structures and also of producing the antibodies that recognize foreign substances.

Sometimes, the immune system fails, can not differentiate the proper from the strange and, finally, acts against the cells of the own body. This failure is what causes the appearance of the known autoimmune diseases.

The immune system is also responsible for the rejections that occur with organ transplants, since it detects that cells from another individual have been introduced and attacked.

The pregnancy

Pregnancy is a special situation in the woman's body, since for 9 months she must gestate a "foreign body".

The embryo has an immune system different from that of the mother, since it is also formed by genes of paternal origin, which are unknown by the mother's immune system.

For the pregnancy to progress normally, the mother's immune system develops a tolerance mechanism to avoid attacking the embryo.

In fact, it is the embryo itself that "warns the mother" through the expression of the HLA G antigen to suppress the cells of the immune system and that it can grow in the uterus.

Immune system in pregnancy

Types of immune infertility

There are many alterations of the immune system and many of them can affect male and / or female fertility, although the latter to a greater extent.

The woman's body can recognize sperm and / or embryo as foreign, which will cause repeated implantation failures or abortions in the first trimester.

Next, we will discuss some types of immunological sterility.

Questions from users


fertility test in Alicante(Spain)

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