In vitro fertilization with donor eggs

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In vitro fertilization (IVF) with egg donation allows a receiving woman to get pregnant using oocytes from a donor and thus be a mother. Ovodonation assisted reproduction treatments, either with the sperm of the couple or with donor semen, are indicated in those patients who can not have children with their own eggs. They are becoming more common due to the high probability of success they offer.

Next you have an index with all the points that we are going to treat in this article.

Index

In vitro fertilization with donor eggs

Indications of ovodonation

This treatment is done when any of the following occurs:

  • Patients without ovarian function, either due to primary ovarian failure, premature ovarian failure or menopause.
  • Patients with ovarian function who have transmissible genetic abnormalities, repeated failures in previous cycles with their own eggs or with more than 40 years of age.

This last cause is the most frequent, because with age, the quality of the oocytes is diminishing: it increases the probability that the obtained embryos present chromosomal abnormalities that compromise its viability and cause abortions. They also greatly increase the chances that the child has Down Syndrome.


Requirements to be an egg donor

Ovodonation is a very controlled process. Therefore, in order to be able to perform, some legal, medical and ethical requirements have to be fulfilled.

Before accessing a donation program, the potential ovodonant must undergo a selection process that values ??their ability to be a donor, in which both their physical state and psychological aspects are studied. In order to be accepted, an egg donor must be between 18 and 35 years of age, in good psychophysical state and not be a carrier of genetic, hereditary or infectious diseases transmissible to offspring.

It should be noted that this is an altruistic, voluntary and totally anonymous process: the identity of the donor will always be confidential.

In the following link more information on this topic appears: Necessary requirements for the donation of ovules in Spain.

Step-by-step ovodonation procedure

Once the donor has been accepted, the ovodonation cycle can be started. The process consists of the following steps:

Ovarian donor stimulation

The ovodonant is performed a hormonal treatment of ovarian stimulation to get more eggs to develop than in a natural cycle, in which only one would mature, and thus increase the chances of success.

The ovule is obtained by follicular puncture. Those who are mature are fertilized in the laboratory with spermatozoa from the recipient's partner or from an anonymous semen donor, depending on the characteristics of each pair. The resulting embryos are kept in culture and their development is evaluated until the embryonic transference is made to the receiving woman.

Ovodonation process

Preparation of endometrial receptor

A few days before the embryo transfer, the recipient undergoes an endometrial preparation treatment. Estrogen and progesterone are administered orally, vaginally or in patches, so that the endometrium reaches the appropriate thickness (7-10 mm) for implantation of the embryo.

The embryo transfer to the uterine cavity of the recipient will be performed between 3 and 6 days after fertilization. The embryo or embryos of better quality will be chosen to be transferred (by law it is established that the maximum is 3) and the rest will be vitrified to be used in the following cycles in the case that pregnancy was not obtained in this one or later if I wish I had more children. About 14 days after the transfer, ?-hCG levels are analyzed to see if gestation has been achieved or not.

Types of ovodonation

Depending on the origin of the ovules, two types of ovodonation are distinguished: the donation with fresh oocytes and with vitrified oocytes.

Donation of eggs in fresh

In these cases, the donor and the recipient have to have the hormonal cycle synchronized, so that the donor is stimulated at the same time that the recipient prepares its endometrium and in the same cycle the egg extraction of the donor and the transfer of the embryos to the uterus of the recipient.

The disadvantage of this technique is that if the donor does not respond well to ovarian stimulation, the recipient may have to wait for the next cycle to perform the transfer.

Donation of vitrified (frozen) eggs

Once oocytes are obtained from the donor, those that are mature are vitrified (ie frozen). Once a compatible recipient is assigned, they will be devitrified and fertilized with the sperm from the recipient's partner or from a compatible semen donor.

As in the previous case, the recipient must have performed the endometrial preparation prior to the embryo transfer, but it will not be in a coordinated way with the donor.

The disadvantage of this method is that the number of eggs available to be fertilized can decrease because they do not all survive thawing. Even so, the survival rates obtained today are very good thanks to the optimization of the oocyte vitrification technique.

Clinical results of oocyte donation

Thanks to the use of good quality oocytes from healthy young women, the success rates of this technique are higher than those of IVF with its own eggs.

According to a study by the Spanish Society of Fertility in 2014, in the case of fresh donation, the percentage of pregnancy per transfer in a cycle of egg donation is 55.9% and delivery rates (newborn in house by transfer) is 36.4%. In the case of vitrified oocyte donation, these percentages decrease somewhat, being 39.7% and 24.7%, respectively.

Donation statistics in fresh and with frozen eggs

If you want more information about the process of egg donation, you can find it at the following link: What is it and how does ovule donation work in Spain?

Prices

Having an IVF with ovulation increases the cost of treatment since the medication has to be paid to stimulate the donor and an economic compensation for the discomfort caused.

If a treatment with IVF / ICSI with own eggs has a cost between 3000 and 5000 ?, when you add ovodonación, its price can vary between 4500 and 9000 ? depending on the assisted reproduction clinic.

The advantage of ovulation is that the eggs are of high quality and the patient usually gets the pregnancy the first time. For this reason, it is possible to save the cost of the accumulated cycles that should be done if the eggs were their own.

In Assisted Reproduction ORG we want to help you achieve pregnancy in a more economical way. That is why we have agreements with Spanish clinics to offer you the first free visit and discounts like the following: IVF discount with egg donor.

User questions

What are the risks of donating eggs?

Many donors, before becoming involved in the ovodonation process, are afraid of the consequences of this technique, since it is believed to be a dangerous procedure and may even cause cancer.

However, oocyte donation is a safe process with very few side effects, of which the donor is informed before starting it in any clinic. One of them is the ovarian hyperstimulation syndrome, which is becoming more and more uncommon.

More information about these risks is detailed in the following link: Is it dangerous to donate eggs?

If I have a child with donor eggs, will it look like me?

The genetic information (DNA) of the transferred embryo will be that of the donor. However, when choosing a donor for a recipient, it is sought that the physical features of both are as similar as possible. Therefore, it is likely to resemble the recipient.

In addition, the maternal environment during pregnancy influences the expression of certain genes (through epigenetics) and may also in some related to physical traits, just as it does in the transmission of certain diseases. However, nothing is known about the topic and more studies need to be done to confirm this.

Does IVF with donor eggs come through Social Security?

In some autonomous communities, it is possible to carry out treatment with ovodonation by Social Security, but not in all. In addition, the requirements to access these treatments will also be different between the autonomous communities.

The experiences that I have read of moms by ovodonación agree that they tell the process to their children but I have doubts, do the experts recommend telling the children?

The decision to tell the children is very personal. However, it is a controversial subject and in general, experts recommend telling it.

In the following link there is more information related to this decision: Tell a child that was born by donation of gametes.

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