Female infertility and cholesterol

-

According to a study published in the journal Human Reproduction, the genetic variation of a gene involved in the regulation of cholesterol can influence female fertility.

To discover the variability of this gene, a blood test has been developed to determine female fertility, used in mice.

Below you have an index with all the points that we will discuss in this article.

Index

Effect of cholesterol

The presence of cholesterol in the bloodstream is influenced by several factors. Among them, several genetic factors involved in the appearance of cholesterol receptors.

One of these receptors is the class B scavenger type 1 (SCARB1). A study conducted by researchers at Johns Hopkins University in the United States, has observed a relationship between the variation in the expression of the gene that codes for this receptor and infertility.

Cholesterol

In the study, carried out and published in Human Reproduction, it has been seen that the variation in this gene is also involved in the production of progesterone in women, which is why it has been related to their fertility.

Conclusion of the studies

The researchers analyzed oocytes and follicular fluids of 274 women with fertility problems and undergoing in vitro fertilization treatments. 207 of these had already undergone the complete IVF cycle, including embryo transfer. Of these women, 9 had a mutation in SCARB1 and none of them had been pregnant after the process. In these 9 were also observed low levels of progesterone, which is considered an essential hormone to maintain pregnancy during its early stages.

With this, you can offer clues about the genetic cause of some types of infertility and also gives options for treatment. That is why, The Massachusetts Institute of Technology has proposed a treatment studied in genetically modified mice. This is a drug for cholesterol that, indirectly, could treat some types of infertility.

We make a great editorial effort. Sharing this article helps us and motivates us to continue our work.

101

Bibliography

Yates M, Kolmakova A, Zhao Y, Rodriguez A. Clinical impact of scavenger receiver class B type I gene polymorphisms on human female fertility. Hum Reprod. 2011 Jul; 26 (7): 1910-6.



Authors and collaborators

Neus Ferrando Embillolaga Degree in Biology from the University of Valencia (UV). Postgraduate in Biotechnology of Human Reproduction Assisted by the Miguel Hernández University of Elche (UHM) with experience as head of the Embryology and Andrology laboratory at the Manzanera Medical Center. More about Neus Ferrando

All about assisted reproduction in our channels.

83,134 4,055 17,769 489


sexual health advice in Malaga(Spain)

Comments

Post a Comment

Popular posts from this blog

Gonal-f pen: doses of 300, 450 and 900 - How does it apply?

-
Gonal-f is a hormonal drug used in assisted reproduction treatments to cause the development of multiple follicles in the ovary. It is composed of the follicle-stimulating hormone (FSH), a gonadotropin that acts in the menstrual cycle of women. There are several formats of Gonal-f in the market, but one of the best known is the one that is administered with a pen-type injector. Below you have an index with all the points that we will discuss in this article. Index 1. Composition and presentation 2. Mode of administration 3. Questions from users 3.1. How should the pen of Gonal-f be preserved? 3.2. What is the use of the Gonal-f pen? 3.3. What happens if I miss a day of giving the dose of Gonal-f? 4. Recommended reading 5. Bibliography 6. Authors and collaborators Questions from users surrogate pregnancy in Tenerife(Spain)
Read more

Fertility treatments in the couple: how to get pregnant?

-
Image
According to the latest report of the Spanish Fertility Society (SEF), in 2016 were carried out 138,553 cycles of in vitro fertilization (IVF) and 36,463 cycles of artificial insemination (AI), which resulted in a total of 37,503 babies born . This represents an increase of 8% in the use of assisted reproduction techniques with respect to the previous year, which shows that more and more couples need help to have the opportunity to become parents. After a year of sexual intercourse without achieving pregnancy, a couple is considered to have sterility problems, so it is advisable to start doing diagnostic tests and determine the most appropriate assisted reproduction treatment in each case, as we will discuss throughout this post. Below you have an index with all the points that we will discuss in this article. Index 1. Custom fertility treatments 2. Artificial insemination (AI) 3. In vitro fertilization (IVF) 3.1. ICSI 3.2. DGP 4. Questions from users 4.1. How muc...
Read more

What is the purpose of the ovitrelle in a fiv treatment?

-
Image
Ovitrelle is a drug that contains recombinant hCG used in assisted reproduction to stimulate ovulation and thus favor pregnancy in the treatments of artificial insemination and in vitro fertilization (IVF). Below you have an index with all the points that we will discuss in this article. Index What is the ovitrelle for in an IVF treatment? 1. Composition 2. Instructions for use 3. Indications and contraindications 4. Risks and adverse effects 5. Ovitrelle and pregnancy test 6. Questions from users 6.1. Is it normal to give ovitrelle after the transfer of the embryos? 6.2. Does the ovitrelle advance the rule? 6.3. Does alcohol consumption negatively affect the effect of ovitrelle? 6.4. What is the price of the ovitrelle ?, does it go into social security? 6.5. Should it be kept in a refrigerator or at room temperature? Composition The active principle of ovitrelle is choriogonadotropin alfa, also called recombinant hCG (human chorionic gonadotropin). The qual...
Read more