Male infertility: seminogram, sperm fish and macs
Although we often associate fertility problems with women, we must bear in mind that infertility is also a man's problem. In fact, between 40 and 50% of reproductive problems are caused by male alterations.
For this reason, in iGin we emphasize the importance of assessing both partners in order to diagnose the problem and give the best solution to achieve pregnancy.
Below you have an index with all the points that we will discuss in this article.
Index
- 1. Causes of infertility
- 2. Fertility tests in man
- 2.1. Seminogram
- 2.2. Karyotype
- 2.3. FISH (In Situ Fluorescent Hybridization)
- 2.4. MACs
- 3. Authors and collaborators
Causes of infertility
Today, about 15% of couples in developed countries have problems having children. This percentage is increasing due to factors such as:
- Delay of motherhood
- Increase in cancer cases
- Increase in genetic diseases
- Lowering the quality of sperm
With regard to this last factor, several reasons have led to this decline. Current life habits, environmental toxins or the intake of harmful substances such as snuff or drugs are some examples that can cause the fragmentation of sperm DNA and lead to the emergence of fertility problems.
Fertility tests in man
As we have indicated, in the face of infertility it is fundamental to analyze the situation of both members of the couple.
In the case of men, the first step is to know their clinical history. Among other things, you will be asked about issues related to reproduction as if you have suffered diseases that can affect your reproductive system such as orchitis, cryptorchidism, varicocele or mumps, or if you have suffered some type of trauma or surgery in the testicular area.
Information on male fertilityIn addition to this initial anamnesis, you will have a blood test and certain genetic studies. These are fundamental since one of the main causes of male infertility concerns genetic and chromosomal alterations. The most common are the karyotype and the spermatic FISH.
Finally, a semengram or spermiogram will be performed, which is no more than a detailed study of the male sperm sample. In it, seminal aspects such as the amount of sperm and its mobility are evaluated.
Here are some of the most important tests:
Seminogram
This is a seminal analysis whose objective is to assess the quality of semen based on seminal factors such as mobility, concentration or sperm morphology as well as volume, viscosity or seminal pH.
The analyzed semen is obtained by masturbation after a period of ejaculatory abstinence of between 3 to 5 days. It is recommended to collect the sample in the clinic itself to deteriorate it as little as possible.
Once the sample is obtained, the diagnosis is obtained after comparing the values ??obtained with the reference values ??set by the WHO (World Health Organization):
- The volume of semen must be greater than 1.5 ml.
- The sperm concentration should be at least 15 million sperm per milliliter.
- Mobility or mobility must exceed 32%.
- The percentage of live sperm in the sample should be at least 58%.
- The morphology must be equal to or greater than 4% of the total sperm.
If the sample is within normal values, this is a case of normozoospermia. If, on the other hand, any of these parameters related to the quality of the sperm is altered, seminal problems may arise, such as the following:
- Hypospermia: low volume of ejaculate
- Hyperespermia: seminal volume greater than 6 ml.
- Oligozoospermia: sperm concentration below the reference value.
- Cryptozoospermia: concentration less than 1 million sperm / ml.
- Astenozoospermia: few motile sperm.
- Necrozoospermia: percentage of live sperm less than 58%.
- Teratozoospermia: less than 4% of sperm have normal morphology.
- Azoospermia: absence of sperm in the ejaculate.
It can also happen that a seminal sample presents several of these pathologies. An example of this is oligoastenoteratozoospermia.
Karyotype
The karyotype is the test that allows analyzing the chromosomal envelope. This is an important test given that about 12.6% of infertile men present alterations in their chromosomes, when this incidence is 0.6% in the control population.
Study of the patient's karyotype
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