Male sterility from a congenital or acquired testicular factor

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Male sterility is defined as the inability of a man's semen to fertilize an egg and lead to pregnancy. There are several factors that can lead man to suffer from this pathology, among them, the testicular cause.

Sterility due to testicular factor refers to all those factors that can directly affect the testicles and prevent achieving a natural pregnancy.

The male sterility of testicular factor can be produced by congenital causes, if they occur from the birth of the individual, or it can be caused later by external agents.

Below you have an index with all the points that we will discuss in this article.

Index

Male sterility from a congenital or acquired testicular factor



Microdeletions of the Y chromosome

The Y chromosome is only found in the male sex and has a smaller size than the rest of chromosomes. When an embryo receives the Y chromosome from the father, instead of the X chromosome, sex is established and a future male will be born.

The Y chromosome, therefore, contains the genes responsible for the formation of the testicles in the chromosomal region called AZF. If there is any alteration in this area or some important genes were not present, the man will suffer a severe male factor that could be from an oligozoospermia to a total secretory azoospermia.

In addition, in case of having a child for assisted reproduction, it can be considered that the future male would also inherit this alteration and suffer male sterility in the future.


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